Anabolic pathway example

The secretion of hypothalamic, pituitary, and target tissue hormones is under tight regulatory control by a series of feedback and feed- forward loops. This complexity can be demonstrated using the growth hormone (GH) regulatory system as an example. The stimulatory substance growth hormone releasing hormone (GHRH) and the inhibitory substance somatostatin (SS) both products of the hypothalamus, control pituitary GH secretion. Somatostatin is also called growth hormone-inhibiting hormone (GHIH). Under the influence of GHRH, growth hormone is released into the systemic circulation, causing the target tissue to secrete insulin-like growth factor-1, IGF-1. Growth hormone also has other more direct metabolic effects; it is both hyperglycemic and lipolytic. The principal source of systemic IGF-1 is the liver, although most other tissues secrete and contribute to systemic IGF-1. Liver IGF-1 is considered to be the principal regulator of tissue growth. In particular, the IGF-1 secreted by the liver is believed to synchronize growth throughout the body, resulting in a homeostatic balance of tissue size and mass. IGF-1 secreted by peripheral tissues is generally considered to be autocrine or paracrine in its biological action.

Several studies concluded that diets low in fat (under 15% of total calories) significantly decreased testosterone levels while diets higher in fat (above 30% of total calories) increased serum testosterone levels. Rather than continuing with this discussion I will provide a link to an article which covers the subject quite nicely. To simplify everything that I have said, it seems that one should not lower fat below 15% of daily calories unless they would like to face extreme testosterone deficiencies. Likewise, one should not increase fat to say 40% in order to increase testosterone. Although fat increases testosterone to a degree, it is important to remember that testosterone is only a small piece of the larger puzzle. There are many other hormones and factors involved in building muscle other than just testosterone. By increasing fat to extremely high levels, there will be less “space” for carbohydrates and protein, both of which are very important for aforementioned reasons.

Anabolic and androgenic steroids are available as prescription medications to be used in cases in which the body does not make enough hormone and supplementation may be required. Some hormone supplements in this pathway include growth hormone and testosterone itself. These medications are legally prescribed by health-care providers, but this group of drugs is often used illegally and abused to help increase athletic performance and improve body appearance. When used in a well-nourished body, anabolic steroids will cause weight gain primarily due to an increase in muscle mass.

Martin,
I've been on your leangain's diet and I am getting accustomed to it already. I am following the workout routine you recommended but I just need your input on how to tweek it to suit my daily routine.

I am an active duty US military, Monday, Wednesday and Friday, we do group sprints and do pushups for an hour (its like an intense cardio session). The nutrition of these days are the "NON Workout Days " of the leangains nutrition guide.

Tuesday, Thursday and Saturday are the LeanGains workout routine and following the "Workout Nutrition" guide.

I'm getting lean but I'm not getting the strength and muscle gains (I am pretty sure its from the sprints and cardio session we have to do 3x a week). Can you recommend me a Nutrition guide for my specific workout load?
Thank you for sharing your knowledge thru your site so EVERYONE can benefit from. Keep up the good work.

Aj
US Active military

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Anabolic pathway example

anabolic pathway example

Martin,
I've been on your leangain's diet and I am getting accustomed to it already. I am following the workout routine you recommended but I just need your input on how to tweek it to suit my daily routine.

I am an active duty US military, Monday, Wednesday and Friday, we do group sprints and do pushups for an hour (its like an intense cardio session). The nutrition of these days are the "NON Workout Days " of the leangains nutrition guide.

Tuesday, Thursday and Saturday are the LeanGains workout routine and following the "Workout Nutrition" guide.

I'm getting lean but I'm not getting the strength and muscle gains (I am pretty sure its from the sprints and cardio session we have to do 3x a week). Can you recommend me a Nutrition guide for my specific workout load?
Thank you for sharing your knowledge thru your site so EVERYONE can benefit from. Keep up the good work.

Aj
US Active military

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