One should be very careful since T3 is a very strong thyroid hormone. It is very important that person begins with a low dosage, increasing dosage slowly. Most athletes begin by taking one 25 mcg tablet per day and increasing this dosage every three to four days by one additional tablet. It is not recommended that the daily dose be taken all at once but broken down into three small doses. It is also important that T3 not be taken for more than six weeks and that the dosage is reduced who take high dosages of Tiromel over a long period of time are at risk of developing a chronic thyroid insufficiency. Possible side effects are trembling of hands, nausea, headaches, high perspiration, and increased heartbeat.