ALT (8-37 IU/L) is present in hepatocytes (liver cells) and is reliable for routine screening for liver disease. It is also called serum glutamate pyruvate transaminase (SGPT) or alanine aminotransferase (ALAT). When a cell is damaged, it leaks this enzyme into the blood, where it is measured. ALT rises dramatically in acute liver damage, such as viral hepatitis or paracetamol (acetaminophen) overdose. The highest level of ALT is in the liver, and levels of this enzyme are accordingly more specific indicators of liver injury. The magnitude of the elevation has no prognostic value and does not correlate with the degree of liver damage.
Obesity is thought to play a role in nonalcoholic fatty liver disease (NAFLD), which affects between 80 and 100 million people in the United States and "will soon be the number-one reason for liver transplantation in the .," says David Bernstein, MD, chief of hepatology at Northwell Health in Manhasset, New York. It happens when too much fat gets stored in liver cells. While experts don’t know exactly what causes NAFLD, the condition is also linked to metabolic syndrome, high blood pressure, and high triglyceride levels, in addition to obesity.
Calcinosis is a rare condition in dogs and is a side effect of high corticosteroid levels in the body; there is a bit of a double edged sword here where the balance between the calcinosis and the lungs needs to be evaluated. It may be worth speaking with an Oncologist to discuss the possible lung cancer and to try and make a definitive diagnosis of which specific cancer may be present, afterwards a treatment protocol with a lower dose of steroids along with other medications will manage the condition. Regards Dr Callum Turner DVM