Cataracts causes steroids

Cataracts never go away on their own, but some stop progressing after a certain point. But if cataracts continue to grow and progress, they can cause blindness if left untreated. Fortunately, cataracts can almost always be successfully treated with surgery. Millions of cataract operations are performed each year in the United States, and there is a very low risk for complications. However, before opting for surgery, patients need to consider on an individual basis how severely a cataract interferes with their quality of life. Cataract surgery is rarely an emergency, so patients have time to consult with their doctors and carefully consider the risks and benefits of surgery.

Also doing certain things may help reduce your risks of developing a cataract, things such as wearing quality sunglasses when outside, whether the sun is bright or not you are still expose to UV healthy is very important, it is suggested that vitamin C and A are beneficial to the eyes
Treatments for cataracts may be as simple as a stronger eyeglass prescription or eye drops, to the more complex solution of surgery. Surgery is typically performed on an outpatient basis and often persons are home the same day. Your optometrist will determine what treatment is right for you.

Steroid-induced posterior subcapsular cataracts (PSCs) exhibit three main distinctive characteristics: (i) association only with steroids possessing glucocorticoid activity, (ii) involvement of aberrant migrating lens epithelial cells, and (iii) a central posterior location. The first characteristic suggests a key role for glucocorticoid receptor activation and subsequent changes to the transcription of specific genes. Glucocorticoid receptor activation is associated in many cell types with proliferation, suppressed differentiation, a reduced susceptibility to apoptosis, altered transmembrane transport, and enhancement of reactive oxygen species activity. Glucocorticoids may be capable of inducing changes to the transcription of genes in lens epithelial cells that are related to many of these cellular processes. This review examines the various mechanisms that have been proposed to account for the development of PSC in the context of recent DNA array studies. Additionally, given that the glucocorticoid receptor can also engender wide-ranging indirect activities, glucocorticoids could also indirectly affect the lens through the responses of other cells within the ocular compartment and/or through effects on cells at more remote locations. These indirect mechanisms, which, for example, could be mediated through alterations to the intraocular levels of growth factors that normally orchestrate lens development and maintain lens homeostasis, are also discussed. Although the mechanism of steroid cataract induction remains unknown, glucocorticoid-induced gene transcription events in lens epithelial cells, and also other intraocular or systemic cells, likely interact to generate steroid cataracts. Finally, although evidence for glucocorticoid-protein adduct formation in the lens is inconclusive, the generation of such adducts cannot yet be discounted as a contributing factor and must necessarily be retained in discussions of the etiology of steroid cataract.

The scientist first tested their theory on human lens cells. The studies showed that when lanosterol was applied to the cells, lens proteins stopped clumping and transparency increased. Next, they studied rabbits suffering from cataracts. After administering lanosterol for six days, 85% of the rabbits had a significant lessening of the severity of their cataracts. Cataracts in dogs were also investigated. Black Labrador Retrievers, Queensland Heelers and Miniature Pinschers, all dogs with significant naturally occurring cataracts, responded in similar fashion as the rabbits.

Cataracts causes steroids

cataracts causes steroids

The scientist first tested their theory on human lens cells. The studies showed that when lanosterol was applied to the cells, lens proteins stopped clumping and transparency increased. Next, they studied rabbits suffering from cataracts. After administering lanosterol for six days, 85% of the rabbits had a significant lessening of the severity of their cataracts. Cataracts in dogs were also investigated. Black Labrador Retrievers, Queensland Heelers and Miniature Pinschers, all dogs with significant naturally occurring cataracts, responded in similar fashion as the rabbits.

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