Corticosteroids in acute asthma exacerbation

We identified 20 trials with 12,303 randomised participants. The effect of corticosteroids on the risk of death was reported in 17 included trials. Due to significant heterogeneity we did not calculate a pooled estimate of the risk of death. The largest trial , with about 80% of all randomised participants, found a significant increase in the risk ratio of death with steroids (95% CI to ) and a relative risk of death or severe disability of (95% CI to ). For infections the pooled risk ratio from five trials was (95% CI to ) and for the ten trials reporting gastrointestinal bleeding (95% CI to ).

Corticosteroids in acute asthma exacerbation

corticosteroids in acute asthma exacerbation

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