In the 1860s, descriptions of boys who grew progressively weaker, lost the ability to walk, and died at an early age became more prominent in medical journals. In the following decade,  French neurologist Guillaume Duchenne gave a comprehensive account of the most common and severe form of the disease, which now carries his name—Duchenne MD. It soon became evident that the disease had more than one form.  The other major forms are Becker, limb-girdle, congenital, facioscapulohumeral, myotonic, oculopharyngeal, distal, and EDMD.  Duchenne and Becker muscular dystrophies, being caused by a mutation of a gene located on the X chromosome, predominantly affect males, although females can sometimes have severe symptoms, as well. Most types of MD are multisystem disorders with manifestations in body systems including the heart, gastrointestinal system, nervous system, endocrine glands, eyes, and brain. 
Acromegaly patients, who suffer from natural growth hormone levels of up to 100 times higher than normal, have lower stamina towards physical activity than people with regular levels.  When the patients are treated and their growth hormone levels decrease, their stamina improves.  This knowledge is part of the evidence behind the new belief that athletes who use supplemental HGH to raise their levels far above average could actually decrease their exercise tolerance, and thus hurt their athletic performance.  Further backing was provided in a study done by the Danish Institute of Sports Medicine. They found cyclists of good health and endurance “were unable to complete accustomed cycling tasks after administration of exogenous hGH” and concluded that HGH can inhibit recuperation from exercise.  Participants have also been found to have lower stamina after HGH treatment along with higher rates of fatigue. 
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