Follistatin is a secreted glycoprotein that was first identified as a folliclestimulating hormone inhibiting substance in ovarian follicular Follistatin cDNA encodes a 344 amino acids protein with a 29 aa signal sequence, an Nterminal atypical TGF binding domain, three Follistatin domains that contain EGF like and kazallike motifs, and a highly acidic Cterminal tail. Follistatin is a secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors..
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