Overall, the overwhelming data and information shows that a good natural test booster will provide incredibly positive and wonderful benefits without any negative side effects . If you look hard enough, you may find a corner case here or there of something minor or annoying, but we haven’t seen them on any consistent type basis and definitely nothing like some of things you may be hearing with testosterone replacement therapies like AndroGel (which is NOT a Test booster….but rather a outside injection of testosterone).That’s because with natural Test boosters, you’re not injecting your body with outside ’re taking natural supplements that trigger and cause your own body to produce more of it’s own testosterone – naturally!
Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes. 
One review  notes that increased rates of depression in society coincide with dietary reduction of Magnesium, with the beginning phases of wheat processing reducing Magnesium content of breads to 19% of their former (wheat) value and reducing the 450mg average intake in the 19th century to 250mg or less in subsequent centuries.  When looking at the diets of persons suffering from depression, there appears to be an inverse relationship between dietary Magnesium intake and depressive symptoms which, although it was attenuated from to (Odds ratio) when controlling for both socioeconomic and lifestyle factors, was still statistically significant.